6 Several studies have shown that SARS-CoV-2 immunoglobulin G (IgG) antibodies are transferred through breast milk. 4, 5 A severe infection in neonates and infants is uncommon 5 despite the suboptimal defense of their humoral immune system. 3 The chance of children becoming infected with COVID-19 is similar to that for adults however, disease in children is usually more subtle. 1 It has been suggested that pregnancies complicated by COVID-19 have a higher risk for preterm birth, cesarean delivery, fetal distress, preeclampsia, 2 and perinatal death. These findings support COVID-19 vaccination of pregnant individuals during the second trimester to achieve maternal protection and newborn safety during the pandemic.ĬOVID-19 can lead to severe respiratory disease in pregnant women as well as quicker disease progression and higher rates of intensive care unit admissions than in the general population. For each 1-year increase in the mother’s age, maternal and neonatal antibody levels changed by −3.1% (95% CI, −5.3% to −0.9% P = .007) and −2.7% (95% CI, −5.2% to −0.1% P = .04), respectively.Ĭonclusions and Relevance In this cohort study, receipt of the BNT162b2 mRNA COVID-19 vaccine during the second trimester of pregnancy was associated with maternal and neonatal humoral responses, as reflected in maternal and neonatal SARS-CoV-2 IgG antibody levels measured after delivery.

Multivariable analysis revealed that for each week that passed since receipt of the second vaccine dose, maternal and neonatal antibody levels changed by −10.9% (95% CI, −17.2% to −4.2% P = .002) and −11.7% (95% CI, −19.0 to −3.8% P = .005), respectively. A positive correlation was demonstrated between maternal and neonatal antibodies ( r = 0.92 95% CI, 0.89-0.94). Neonatal IgG titers were 2.6 times higher than maternal titers (median, 3315.7 AU/mL vs 1185.2 AU/mL). The mean (SD) gestational age at administration of the second vaccine dose was 24.9 (3.3) weeks. Results Antibody levels were measured for 129 women (mean age, 31.9 years) and 114 neonates, with 100% of the tests having positive results. Secondary outcomes were the correlation between antibody titers, feto-maternal characteristics, maternal adverse effects after vaccination, and time interval from vaccination to delivery. Main Outcomes and Measures The primary outcomes were SARS-CoV-2 IgG antibody titers measured in the parturient at admission and in the umbilical cord blood within 30 minutes after delivery. Objective To evaluate maternal and neonatal SARS-CoV-2 immunoglobulin G (IgG) antibody levels at birth after mRNA COVID-19 vaccination during the second trimester of pregnancy.ĭesign, Setting, and Participants This prospective cohort study, conducted at a single medical center in Haifa, Israel, from May to July 2021, included women with a singleton pregnancy over 24 weeks of gestation at least 7 days after receipt of their second COVID-19 vaccine dose who were not known to be previously infected with COVID-19.Įxposures BNT162b2 (Pfizer/BioNTech) vaccination. Importance BNT162b2 messenger RNA (mRNA) COVID-19 vaccination in the third trimester was found to be associated with a strong maternal humoral IgG response that crossed the placenta and approached maternal titers in the newborn. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.

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